SidaGhanaV1, Main, Exploration, bibRecord, 001385

Presence of human T lymphotropic virus types I and II in Ghana, west Africa.

Identifieur interne : 001385 ( Main/Exploration ); précédent : 001384; suivant : 001386

Presence of human T lymphotropic virus types I and II in Ghana, west Africa.

Auteurs : R B Lal [États-Unis] ; S M Owen ; J. Mingle ; P H Levine ; A. Manns

Source :

AIDS research and human retroviruses [ 0889-2229 ] ; 1994.

RBID : pubmed:7888235

Descripteurs français

KwdFr :
- Anticorps antiviraux (immunologie), Enfant, Enregistrements, Facteurs de risque, Femelle, Ghana (épidémiologie), Grossesse, Humains, Infections à HTLV-I (virologie), Infections à HTLV-I (épidémiologie), Infections à HTLV-II (virologie), Infections à HTLV-II (épidémiologie), Prévalence, Virus T-lymphotrope humain de type 1 (isolement et purification), Virus T-lymphotrope humain de type 2 (isolement et purification), Études séroépidémiologiques.
MESH :
- immunologie : Anticorps antiviraux.
- isolement et purification : Virus T-lymphotrope humain de type 1, Virus T-lymphotrope humain de type 2.
- virologie : Infections à HTLV-I, Infections à HTLV-II.
- épidémiologie : Ghana, Infections à HTLV-I, Infections à HTLV-II.
- Enfant, Enregistrements, Facteurs de risque, Femelle, Grossesse, Humains, Prévalence, Études séroépidémiologiques.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Antibodies, Viral (immunology), Child, Female, Ghana (epidemiology), HTLV-I Infections (epidemiology), HTLV-I Infections (virology), HTLV-II Infections (epidemiology), HTLV-II Infections (virology), Human T-lymphotropic virus 1 (isolation & purification), Human T-lymphotropic virus 2 (isolation & purification), Humans, Pregnancy, Prevalence, Registries, Risk Factors, Seroepidemiologic Studies.
MESH :
- chemical , immunology : Antibodies, Viral.
- geographic , epidemiology : Ghana.
- epidemiology : HTLV-I Infections, HTLV-II Infections.
- isolation & purification : Human T-lymphotropic virus 1, Human T-lymphotropic virus 2.
- virology : HTLV-I Infections, HTLV-II Infections.
- Child, Female, Humans, Pregnancy, Prevalence, Registries, Risk Factors, Seroepidemiologic Studies.

Abstract

Until recently, HTLV-I was considered to be an Old World virus and HTLV-II was thought to be endemic in the Americas. However, the presence of HTLV-II among Pygmies and other populations of Africa has raised doubts as to whether HTLV-II is primarily a New World virus. The large serosurveys conducted in the urban and rural areas of southern Ghana have identified a 1-2% prevalence for HTLV-I/II. To define the HTLV type, we have used a Western blot assay (HTLV-2.3 blot) that allows simultaneous confirmation and differentiation between HTLVs. Samples (n = 139) were chosen on the basis of previous reactivity with either an enzyme immune assay or r21e-spiked WB results. The WB 2.3 analysis of these specimens identified 55 (40%) to be HTLV positive, 70 (50%) to be HTLV indeterminant, and 14 (10%) to be HTLV negative for HTLV. HTLV seroindeterminant patterns ranged from both gag and env (14 were r21+, p24+, and/or p19+ [all were RIPA negative]) to gag only (21 were p24+/p19+, 16 were p19+, and 7 were p24+), and env only (8 were r21+ and 4 were rgp46+) reactivities. Of the 55 HTLV-positive specimens, 41 were typed as HTLV-I, 9 were HTLV-II, and 5 could not be typed (HTLV-I/II). Of the nine HTLV-II-positive specimens, three were from patients with Burkitt's lymphoma and six were from healthy individuals (two pregnant women) with no obvious risk factors for HTLV-II.(ABSTRACT TRUNCATED AT 250 WORDS)

DOI: 10.1089/aid.1994.10.1747
PubMed: 7888235

Affiliations:

Le document en format XML

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<term>HTLV-I Infections (epidemiology)</term>
<term>HTLV-I Infections (virology)</term>
<term>HTLV-II Infections (epidemiology)</term>
<term>HTLV-II Infections (virology)</term>
<term>Human T-lymphotropic virus 1 (isolation & purification)</term>
<term>Human T-lymphotropic virus 2 (isolation & purification)</term>
<term>Humans</term>
<term>Pregnancy</term>
<term>Prevalence</term>
<term>Registries</term>
<term>Risk Factors</term>
<term>Seroepidemiologic Studies</term>
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<term>Enfant</term>
<term>Enregistrements</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Ghana (épidémiologie)</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Infections à HTLV-I (virologie)</term>
<term>Infections à HTLV-I (épidémiologie)</term>
<term>Infections à HTLV-II (virologie)</term>
<term>Infections à HTLV-II (épidémiologie)</term>
<term>Prévalence</term>
<term>Virus T-lymphotrope humain de type 1 (isolement et purification)</term>
<term>Virus T-lymphotrope humain de type 2 (isolement et purification)</term>
<term>Études séroépidémiologiques</term>
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<term>Infections à HTLV-II</term>
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<term>Grossesse</term>
<term>Humains</term>
<term>Prévalence</term>
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<front><div type="abstract" xml:lang="en">Until recently, HTLV-I was considered to be an Old World virus and HTLV-II was thought to be endemic in the Americas. However, the presence of HTLV-II among Pygmies and other populations of Africa has raised doubts as to whether HTLV-II is primarily a New World virus. The large serosurveys conducted in the urban and rural areas of southern Ghana have identified a 1-2% prevalence for HTLV-I/II. To define the HTLV type, we have used a Western blot assay (HTLV-2.3 blot) that allows simultaneous confirmation and differentiation between HTLVs. Samples (n = 139) were chosen on the basis of previous reactivity with either an enzyme immune assay or r21e-spiked WB results. The WB 2.3 analysis of these specimens identified 55 (40%) to be HTLV positive, 70 (50%) to be HTLV indeterminant, and 14 (10%) to be HTLV negative for HTLV. HTLV seroindeterminant patterns ranged from both gag and env (14 were r21+, p24+, and/or p19+ [all were RIPA negative]) to gag only (21 were p24+/p19+, 16 were p19+, and 7 were p24+), and env only (8 were r21+ and 4 were rgp46+) reactivities. Of the 55 HTLV-positive specimens, 41 were typed as HTLV-I, 9 were HTLV-II, and 5 could not be typed (HTLV-I/II). Of the nine HTLV-II-positive specimens, three were from patients with Burkitt's lymphoma and six were from healthy individuals (two pregnant women) with no obvious risk factors for HTLV-II.(ABSTRACT TRUNCATED AT 250 WORDS)</div>
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Le SIDA au Ghana (serveur d'exploration)

Presence of human T lymphotropic virus types I and II in Ghana, west Africa.

Presence of human T lymphotropic virus types I and II in Ghana, west Africa.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Le SIDA au Ghana (serveur d'exploration)
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